Summary

Physiological Saline Market Summary

The global physiological saline market size was estimated at USD 5.24 billion in 2024 and is projected to reach USD 9.54 billion by 2033, growing at a CAGR of 6.97% from 2025 to 2033. The growth of the industry is attributed to the rising number of surgical procedures, prevalence of chronic diseases such as kidney disorders requiring dialysis, and the extensive use of saline in IV infusions for hydration and drug delivery.

Increasing applications in wound irrigation, ophthalmic procedures, and nasal care further expand demand. In addition, the shift toward home-based healthcare, an aging global population with higher hospitalization needs, and continuous product innovations in packaging formats such as flexible containers and small-volume vials are fueling market growth.

Rising inpatient admissions and the increasing reliance on IV therapy are major factors driving the physiological saline industry. Saline is the most commonly used IV fluid for hydration, electrolyte balance, and as a carrier for medications in hospitalized patients. With the growing incidence of chronic illnesses, infectious diseases, and emergency admissions, hospitals are witnessing higher demand for large-volume saline solutions in flexible containers and bottles. The expansion of critical care units, coupled with a preference for IV therapy in both acute and long-term treatment settings, directly fuels the steady growth of the market.

High and rising surgical volumes are a major driver of the physiological saline industry, as sterile 0.9% saline is a critical requirement in nearly all procedures for wound irrigation, tissue cleaning, fluid replacement, and IV infusion. The increasing global burden of chronic diseases, trauma cases, and elective surgeries is fueling the demand for saline solutions across hospitals and surgical centers, supported by their use in general, orthopedic, cardiovascular, and ophthalmic surgeries. According to the 2024 Procedural Statistics Release, approximately 1,585,878 cosmetic surgeries were performed in 2024, representing a 1% increase compared to 2023, while reconstructive procedures rose by 2% during the same period, underscoring steady growth in surgical interventions. Similarly, data from the Aesthetic Society highlighted that cosmetic surgical procedures grew 2.9% from 2022 to 2023, reflecting the continuous expansion of surgical volumes and reinforcing the rising demand for physiological saline.

The rising prevalence of chronic wounds, particularly diabetic foot ulcers and pressure ulcers, is a significant driver of the market for physiological saline, as these conditions require frequent wound cleaning and irrigation with sterile saline to prevent infection and promote healing. In March 2025, MDPI noted diabetic foot as one of the most serious complications of diabetes, affecting around 18.6 million people globally each year and accounting for nearly 80% of diabetes-related lower limb amputations. It is estimated that up to 25% of individuals with diabetes are at risk of developing diabetic foot, with 19%–34% likely to experience ulcers during their lifetime. Supporting this, a JAMA study in November 2023 reported that one in three diabetic patients (33.33%) develops foot ulcers, impacting 1.6 million individuals annually in the U.S., while Trios Health (October 2023) noted that around 2 million Americans develop diabetic foot ulcers each year. Such wounds' high incidence and recurrence drive consistent demand for physiological saline solutions as an essential component of wound management.

The expansion of home and outpatient care is driving the market for physiological saline by increasing demand for convenient, smaller-volume packaging formats such as vials, prefilled syringes, and flexible containers. With the growing shift toward cost-effective and patient-centered healthcare, more treatments such as IV infusions, wound irrigation, nasal care, and ophthalmic procedures are being managed outside traditional hospital settings. This trend is particularly supported by the rising elderly population, chronic disease management needs, and advancements in portable infusion systems. As a result, the accessibility and ease of use of saline solutions in home and outpatient environments are fueling steady market growth.

The FDA’s approval of Baxter’s Sabinanigo, Spain, facility as a manufacturing site for 0.9% Sodium Chloride Injection, USP, is a key development for the U.S. physiological saline market. This move enhances supply security and addresses the ongoing shortages of saline solutions impacting healthcare providers. By adding new production capacity and ensuring availability in multiple volumes (250 mL, 500 mL, and 1000 mL), the approval strengthens the resilience of the saline supply chain and supports uninterrupted clinical use across hospitals and surgical centers, thereby driving market growth.

Global Physiological Saline Market Report Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Grand View Research has segmented the global physiological saline market report on the basis of product, container, volume, end use, and region:

• Product Outlook (Revenue, USD Million, 2021 - 2033)
• Intravenous (IV) Saline Solutions
• Nasal Irrigation Solutions
• Ophthalmic Saline
• Wound Irrigation and Cleaning Solutions
• Container Outlook (Revenue, USD Million, 2021 - 2033)
• Flexible Container
• Plastic Bottles
• Vial
• Volume Outlook (Revenue, USD Million, 2021 - 2033)
• 1000 ML
• 500 ML
• 250 ML
• Less Than 250
• More Than 1000 ml
• End Use Outlook (Revenue, USD Million, 2021 - 2033)
• Hospitals & Clinics
• Ambulatory Surgical Centers (ASCs)
• Home Care Settings
• Laboratory & Research
• Regional Outlook (Revenue, USD Million, 2021 - 2033)
• North America
o U.S.
o Canada
o Mexico
• Europe
o UK
o Germany
o France
o Italy
o Spain
o Denmark
o Sweden
o Norway
• Asia Pacific
o Japan
o China
o India
o Australia
o Thailand
o South Korea
• Latin America
o Brazil
o Argentina
• Middle East & Africa
o South Africa
o Saudi Arabia
o UAE
o Kuwait

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Table of Contents

Table of Contents

Chapter 1. Methodology and Scope
1.1. Market Segmentation & Scope
1.2. Research Methodology
1.3. Information Procurement
1.3.1. Purchased database.
1.3.2. GVR’s internal database
1.3.3. Secondary sources
1.3.4. Third Party Perspective
1.3.5. Primary research
1.3.6. Details of primary research
1.4. Information or Data Analysis
1.4.1. Data analysis models
1.5. Market Formulation & Validation
1.6. Model Details
1.6.1. Commodity flow analysis (Model 1)
1.7. Approach 1: Commodity flow approach
1.7.1. Volume price analysis (Model 2)
1.8. Approach 2: Volume price analysis
1.9. List of Secondary Sources
1.10. List of Primary Sources
1.11. List of Abbreviations
Chapter 2. Executive Summary
2.1. Market Outlook
2.2. Segment Outlook
2.3. Competitive Insights
Chapter 3. Physiological Saline Market Variables, Trends, & Scope
3.1. Market Lineage Outlook
3.1.1. Ancillary Market Outlook
3.2. Market Dynamics
3.2.1. Market Driver Analysis
3.2.1.1. High and Growing Surgical Volumes
3.2.1.2. Rising Inpatient Care and IV Therapy Use
3.2.1.3. Increasing Prevalence Of Chronic Diseases
3.2.2. Market Restraint Analysis
3.2.2.1. Low Product Differentiation & Commoditization
3.2.2.2. Supply Chain Vulnerabilities
3.2.3. Market Opportunities Analysis
3.2.3.1. Growing Demand in Emerging Economies
3.2.3.2. Expansion of Home and Outpatient Care
3.2.3.3. Product Innovation in Packaging
3.2.4. Market Challenges Analysis
3.2.4.1. Recurring shortages and recalls
3.3. Physiological Saline Market Analysis Tools
3.3.1. Industry Analysis - Porter’s
3.3.1.1. Bargaining Power of Suppliers
3.3.1.2. Bargaining Power of Buyers
3.3.1.3. Threat of Substitutes
3.3.1.4. Threat of New Entrants
3.3.1.5. Competitive Rivalry
3.3.2. PESTEL Analysis
3.3.2.1. Political & Legal Landscape
3.3.2.2. Economic and Social Landscape
3.3.2.3. Technological Landscape
Chapter 4. Physiological Saline Market: Product Estimates & Trend Analysis
4.1. Segment Dashboard
4.2. Physiological Saline Market: Product Movement Analysis & Market Share, 2024 & 2033
4.3. Intravenous (IV) Saline Solutions
4.3.1. Intravenous (IV) Saline Solutions Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
4.4. Nasal Irrigation Solutions
4.4.1. Nasal Irrigation Solutions Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
4.5. Ophthalmic Saline
4.5.1. Ophthalmic Saline Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
4.6. Wound Irrigation and Cleaning Solutions
4.6.1. Wound Irrigation and Cleaning Solutions Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
Chapter 5. Physiological Saline Market: Container Estimates & Trend Analysis
5.1. Segment Dashboard
5.2. Physiological Saline Market: Container Movement Analysis & Market Share, 2024 & 2033
5.3. Flexible Container
5.3.1. Flexible Container Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.4. Plastic Bottles
5.4.1. Plastic Bottles Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.5. Vial
5.5.1. Vial Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
Chapter 6. Physiological Saline Market: Volume Estimates & Trend Analysis
6.1. Segment Dashboard
6.2. Physiological Saline Market: Volume Movement Analysis & Market Share, 2024 & 2033
6.3. 1000 ML
6.3.1. 1000 ML Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
6.4. 500 ML
6.4.1. 500 ML Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
6.5. 250 ML
6.5.1. 250 ML Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
6.6. Less Than 250 ML
6.6.1. Less Than 250 ML Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
6.7. More Than 1000 ML
6.7.1. More Than 1000 ML Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
Chapter 7. Physiological Saline Market: End Use Estimates & Trend Analysis
7.1. Segment Dashboard
7.2. Physiological Saline Market: End Use Movement Analysis & Market Share, 2024 & 2033
7.3. Hospitals & Clinics
7.3.1. Hospitals & Clinics Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
7.4. Ambulatory Surgical Centers
7.4.1. Ambulatory Surgical Centers Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
7.5. Home Care Settings
7.5.1. Home Care Settings Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
7.6. Laboratory & Research
7.6.1. Laboratory & Research Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
Chapter 8. Physiological Saline Market: Regional Estimates & Trend Analysis by Product, Container, Volume, End Use
8.1. Regional Outlook
8.2. Physiological Saline Market: Regional Movement Analysis & Market Share, 2024 & 2033
8.3. North America
8.3.1. North America Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.3.2. U.S.
8.3.2.1. Key Country Dynamics
8.3.2.2. Competitive Scenario
8.3.2.3. Regulatory Scenario
8.3.2.4. Reimbursement Scenario
8.3.2.5. U.S. Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.3.3. Canada
8.3.3.1. Key Country Dynamics
8.3.3.2. Competitive Scenario
8.3.3.3. Regulatory Scenario
8.3.3.4. Reimbursement Scenario
8.3.3.5. Canada Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.3.4. Mexico
8.3.4.1. Key Country Dynamics
8.3.4.2. Competitive Scenario
8.3.4.3. Regulatory Scenario
8.3.4.4. Reimbursement Scenario
8.3.4.5. Mexico Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.4. Europe
8.4.1. Europe Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.4.2. UK
8.4.2.1. Key Country Dynamics
8.4.2.2. Competitive Scenario
8.4.2.3. Regulatory Scenario
8.4.2.4. Reimbursement Scenario
8.4.2.5. UK Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.4.3. Germany
8.4.3.1. Key Country Dynamics
8.4.3.2. Competitive Scenario
8.4.3.3. Regulatory Scenario
8.4.3.4. Reimbursement Scenario
8.4.3.5. Germany Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.4.4. France
8.4.4.1. Key Country Dynamics
8.4.4.2. Competitive Scenario
8.4.4.3. Regulatory Scenario
8.4.4.4. Reimbursement Scenario
8.4.4.5. France Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.4.5. Italy
8.4.5.1. Key Country Dynamics
8.4.5.2. Competitive Scenario
8.4.5.3. Regulatory Scenario
8.4.5.4. Reimbursement Scenario
8.4.5.5. Italy Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.4.6. Spain
8.4.6.1. Key Country Dynamics
8.4.6.2. Competitive Scenario
8.4.6.3. Regulatory Scenario
8.4.6.4. Reimbursement Scenario
8.4.6.5. Spain Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.4.7. Denmark
8.4.7.1. Key Country Dynamics
8.4.7.2. Competitive Scenario
8.4.7.3. Regulatory Scenario
8.4.7.4. Reimbursement Scenario
8.4.7.5. Denmark Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.4.8. Sweden
8.4.8.1. Key Country Dynamics
8.4.8.2. Competitive Scenario
8.4.8.3. Regulatory Scenario
8.4.8.4. Reimbursement Scenario
8.4.8.5. Sweden Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.4.9. Norway
8.4.9.1. Key Country Dynamics
8.4.9.2. Competitive Scenario
8.4.9.3. Regulatory Scenario
8.4.9.4. Reimbursement Scenario
8.4.9.5. Norway Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.5. Asia Pacific
8.5.1. Asia Pacific Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.5.2. Japan
8.5.2.1. Key Country Dynamics
8.5.2.2. Competitive Scenario
8.5.2.3. Regulatory Scenario
8.5.2.4. Reimbursement Scenario
8.5.2.5. Japan Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.5.3. China
8.5.3.1. Key Country Dynamics
8.5.3.2. Competitive Scenario
8.5.3.3. Regulatory Scenario
8.5.3.4. Reimbursement Scenario
8.5.3.5. China Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.5.4. India
8.5.4.1. Key Country Dynamics
8.5.4.2. Competitive Scenario
8.5.4.3. Regulatory Scenario
8.5.4.4. Reimbursement Scenario
8.5.4.5. India Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.5.5. South Korea
8.5.5.1. Key Country Dynamics
8.5.5.2. Competitive Scenario
8.5.5.3. Regulatory Scenario
8.5.5.4. Reimbursement Scenario
8.5.5.5. South Korea Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.5.6. Australia
8.5.6.1. Key Country Dynamics
8.5.6.2. Competitive Scenario
8.5.6.3. Regulatory Scenario
8.5.6.4. Reimbursement Scenario
8.5.6.5. Australia Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.5.7. Thailand
8.5.7.1. Key Country Dynamics
8.5.7.2. Competitive Scenario
8.5.7.3. Regulatory Scenario
8.5.7.4. Reimbursement Scenario
8.5.7.5. Thailand Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.6. Latin America
8.6.1. Latin America Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.6.2. Brazil
8.6.2.1. Key Country Dynamics
8.6.2.2. Competitive Scenario
8.6.2.3. Regulatory Scenario
8.6.2.4. Reimbursement Scenario
8.6.2.5. Brazil Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.6.3. Argentina
8.6.3.1. Key Country Dynamics
8.6.3.2. Competitive Scenario
8.6.3.3. Regulatory Scenario
8.6.3.4. Reimbursement Scenario
8.6.3.5. Argentina Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.7. Middle East & Africa
8.7.1. Middle East & Africa Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.7.2. South Africa
8.7.2.1. Key Country Dynamics
8.7.2.2. Competitive Scenario
8.7.2.3. Regulatory Scenario
8.7.2.4. Reimbursement Scenario
8.7.2.5. South Africa Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.7.3. Saudi Arabia
8.7.3.1. Key Country Dynamics
8.7.3.2. Competitive Scenario
8.7.3.3. Regulatory Scenario
8.7.3.4. Reimbursement Scenario
8.7.3.5. Saudi Arabia Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.7.4. UAE
8.7.4.1. Key Country Dynamics
8.7.4.2. Competitive Scenario
8.7.4.3. Regulatory Scenario
8.7.4.4. Reimbursement Scenario
8.7.4.5. UAE Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
8.7.5. Kuwait
8.7.5.1. Key Country Dynamics
8.7.5.2. Competitive Scenario
8.7.5.3. Regulatory Scenario
8.7.5.4. Reimbursement Scenario
8.7.5.5. Kuwait Physiological Saline Market Estimates and Forecasts, 2021 - 2033 (USD Million)
Chapter 9. Competitive Landscape
9.1. Market Participant Categorization
9.2. Key Company Profiles
9.2.1. B. Braun Medical Inc.
9.2.1.1. Company Overview
9.2.1.2. Financial Performance
9.2.1.3. Product Benchmarking
9.2.1.4. Strategic Initiatives
9.2.2. Baxter
9.2.2.1. Company Overview
9.2.2.2. Financial Performance
9.2.2.3. Product Benchmarking
9.2.2.4. Strategic Initiatives
9.2.3. Fresenius SE & Co. KGaA
9.2.3.1. Company Overview
9.2.3.2. Financial Performance
9.2.3.3. Product Benchmarking
9.2.3.4. Strategic Initiatives
9.2.4. Pfizer Inc.
9.2.4.1. Company Overview
9.2.4.2. Financial Performance
9.2.4.3. Product Benchmarking
9.2.4.4. Strategic Initiatives
9.2.5. ICU Medical, Inc.
9.2.5.1. Company Overview
9.2.5.2. Financial Performance
9.2.5.3. Product Benchmarking
9.2.5.4. Strategic Initiatives
9.2.6. Medline Industries, LP.
9.2.6.1. Company Overview
9.2.6.2. Financial Performance
9.2.6.3. Product Benchmarking
9.2.6.4. Strategic Initiatives
9.2.7. AirLife
9.2.7.1. Company Overview
9.2.7.2. Financial Performance
9.2.7.3. Product Benchmarking
9.2.7.4. Strategic Initiatives
9.2.8. Amsino International, Inc.
9.2.8.1. Company Overview
9.2.8.2. Financial Performance
9.2.8.3. Product Benchmarking
9.2.8.4. Strategic Initiatives
9.2.9. AdvaCare Pharma
9.2.9.1. Company Overview
9.2.9.2. Financial Performance
9.2.9.3. Product Benchmarking
9.2.9.4. Strategic Initiatives
9.2.10. Advin Health Care
9.2.10.1. Company Overview
9.2.10.2. Financial Performance
9.2.10.3. Product Benchmarking
9.2.10.4. Strategic Initiatives
9.2.11. WAMIN (Suppliers, Exporters, and Manufacturers China Medicine)
9.2.11.1. Company Overview
9.2.11.2. Financial Performance
9.2.11.3. Product Benchmarking
9.2.11.4. Strategic Initiatives
9.3. Company Market Share Analysis, 2024