Summary

Market Overview
The Global Protein Engineering Market was valued at USD 2.87 billion in 2024 and is projected to reach USD 5.74 billion by 2030, growing at a CAGR of 12.25% during the forecast period. Protein engineering is a specialized branch of biotechnology that focuses on designing, modifying, and optimizing proteins to enhance or create new functionalities. These proteins serve vital roles in catalysis, signaling, molecular transport, and structural integrity within living systems. Technological advancements in molecular biology now allow researchers to synthesize and alter genes encoding specific proteins, facilitating the development of novel and improved biological molecules. As the demand grows for engineered proteins in applications ranging from therapeutic antibodies to agricultural innovations, the market continues to expand rapidly. Government-backed research funding, growing private investments, and innovation-driven initiatives—such as AI-enabled drug design—are accelerating market development. For instance, Nabla Bio raised USD 11 million in 2021 to build an AI-first platform for next-generation antibody therapeutics, exemplifying the momentum in this sector.
Key Market Drivers
Technological Advancements
Cutting-edge technologies have been instrumental in driving the evolution and expansion of protein engineering applications across sectors such as healthcare, agriculture, and industrial biotechnology. CRISPR-Cas9 has revolutionized gene editing by enabling precise, efficient protein modifications. Directed evolution techniques allow researchers to mimic natural selection in the laboratory to optimize protein functions through iterative mutation and screening. High-throughput screening (HTS) systems have improved the speed and scale of protein testing, enabling rapid identification of proteins with desirable traits. Computational tools, including AI and molecular modeling, now support accurate protein structure predictions and help streamline the design process. Synthetic biology allows for de novo construction of proteins with tailored functionalities, while advances in protein expression systems (yeast, bacterial, and mammalian) have enhanced recombinant protein yields and quality. Collectively, these innovations are facilitating the development of therapeutic proteins, industrial enzymes, and bioengineered agricultural products with unprecedented efficiency.
Key Market Challenges
Complexity of Protein Design
One of the primary challenges in protein engineering is the inherent complexity of protein design. Proteins rely on intricate three-dimensional folding to function correctly, and even minor alterations in amino acid sequences can result in misfolding and loss of activity. Designing proteins that not only fold properly but also exhibit desired properties—such as stability, specificity, and bioactivity—is a highly complex task. Predicting functional outcomes, ensuring correct protein-ligand or protein-protein interactions, and maintaining stability under physiological conditions remain difficult. Additionally, successful protein design demands multidisciplinary expertise in structural biology, computational modeling, bioinformatics, and chemistry, making collaboration essential. These scientific and technical hurdles limit the pace of development and adoption in certain application areas, especially where precision and reproducibility are critical.
Key Market Trends
Expansion of Protein Engineering in Agriculture
Protein engineering is witnessing a growing footprint in agricultural biotechnology. By modifying plant proteins and enzymes, researchers are enhancing crop traits such as pest resistance, disease tolerance, and resilience to environmental stressors like drought and salinity. Engineered crops can also be enriched with essential nutrients, addressing malnutrition through biofortification. These advances reduce the need for chemical inputs like pesticides and fertilizers, promoting more sustainable and eco-friendly farming practices. Protein engineering enables the development of genetically modified organisms (GMOs) with targeted improvements, supporting food security and environmental sustainability. The trend toward nutrient-dense and climate-resilient crops underscores the increasing role of protein engineering in transforming agriculture globally.
Key Market Players
• Agilent Technologies Inc.
• Amgen Inc.
• Bruker Corporation
• Bio-Rad Laboratories Inc.
• Eli Lilly and Company
• Merck KGaA
• Novo Nordisk AS
• PerkinElmer Inc.
• Thermo Fisher Scientific Inc.
• Waters Corporation
Report Scope:
In this report, the Global Protein Engineering Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:
• Protein Engineering Market, By Product Type:
o Insulin
o Monoclonal Antibodies
o Coagulation Factors (Blood Factors + Tissue Plasminogen)
o Vaccines
o Growth Factors (Hormones + Cytokine)
o Other Product Types
• Protein Engineering Market, By Technology:
o Irrational Protein Design
o Rational Protein Design
• Protein Engineering Market, By End User:
o Pharmaceutical and Biotechnology Companies
o Academic Institutions
o Contract Research Organizations (CROs)
• Protein Engineering Market, By Region:
o North America
§ United States
§ Canada
§ Mexico
o Asia-Pacific
§ China
§ India
§ South Korea
§ Australia
§ Japan
o Europe
§ Germany
§ France
§ United Kingdom
§ Spain
§ Italy
o South America
§ Brazil
§ Argentina
§ Colombia
o Middle East & Africa
§ South Africa
§ Saudi Arabia
§ UAE
Competitive Landscape
Company Profiles: Detailed analysis of the major companies present in the Global Protein Engineering Market.
Available Customizations:
Global Protein Engineering Market report with the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report:
Company Information
• Detailed analysis and profiling of additional market players (up to five).

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Table of Contents

1. Product Overview
1.1. Market Definition
1.2. Scope of the Market
1.2.1. Markets Covered
1.2.2. Years Considered for Study
1.2.3. Key Market Segmentations
2. Research Methodology
2.1. Objective of the Study
2.2. Baseline Methodology
2.3. Key Industry Partners
2.4. Major Association and Secondary Sources
2.5. Forecasting Methodology
2.6. Data Triangulation & Validation
2.7. Assumptions and Limitations
3. Executive Summary
3.1. Overview of the Market
3.2. Overview of Key Market Segmentations
3.3. Overview of Key Market Players
3.4. Overview of Key Regions/Countries
3.5. Overview of Market Drivers, Challenges, Trends
4. Voice of Customer
5. Global Protein Engineering Market Outlook
5.1. Market Size & Forecast
5.1.1. By Value
5.2. Market Share & Forecast
5.2.1. By Product Type (Insulin, Monoclonal Antibodies, Coagulation Factors (Blood Factors + Tissue Plasminogen), Vaccines, Growth Factors (Hormones + Cytokine), and Other Product Types)
5.2.2. By Technology (Irrational Protein Design and Rational Protein Design)
5.2.3. By End User (Pharmaceutical and Biotechnology Companies, Academic Institutions, and Contract Research Organizations (CROs))
5.2.4. By Region
5.2.5. By Company (2024)
5.3. Market Map
6. Asia Pacific Protein Engineering Market Outlook
6.1. Market Size & Forecast
6.1.1. By Value
6.2. Market Share & Forecast
6.2.1. By Product Type
6.2.2. By Technology
6.2.3. By End User
6.2.4. By Country
6.3. Asia Pacific: Country Analysis
6.3.1. China Protein Engineering Market Outlook
6.3.1.1. Market Size & Forecast
6.3.1.1.1. By Value
6.3.1.2. Market Share & Forecast
6.3.1.2.1. By Product Type
6.3.1.2.2. By Technology
6.3.1.2.3. By End User
6.3.2. India Protein Engineering Market Outlook
6.3.2.1. Market Size & Forecast
6.3.2.1.1. By Value
6.3.2.2. Market Share & Forecast
6.3.2.2.1. By Product Type
6.3.2.2.2. By Technology
6.3.2.2.3. By End User
6.3.3. Australia Protein Engineering Market Outlook
6.3.3.1. Market Size & Forecast
6.3.3.1.1. By Value
6.3.3.2. Market Share & Forecast
6.3.3.2.1. By Product Type
6.3.3.2.2. By Technology
6.3.3.2.3. By End User
6.3.4. Japan Protein Engineering Market Outlook
6.3.4.1. Market Size & Forecast
6.3.4.1.1. By Value
6.3.4.2. Market Share & Forecast
6.3.4.2.1. By Product Type
6.3.4.2.2. By Technology
6.3.4.2.3. By End User
6.3.5. South Korea Protein Engineering Market Outlook
6.3.5.1. Market Size & Forecast
6.3.5.1.1. By Value
6.3.5.2. Market Share & Forecast
6.3.5.2.1. By Product Type
6.3.5.2.2. By Technology
6.3.5.2.3. By End User
7. Europe Protein Engineering Market Outlook
7.1. Market Size & Forecast
7.1.1. By Value
7.2. Market Share & Forecast
7.2.1. By Product Type
7.2.2. By Technology
7.2.3. By End User
7.2.4. By Country
7.3. Europe: Country Analysis
7.3.1. France Protein Engineering Market Outlook
7.3.1.1. Market Size & Forecast
7.3.1.1.1. By Value
7.3.1.2. Market Share & Forecast
7.3.1.2.1. By Product Type
7.3.1.2.2. By Technology
7.3.1.2.3. By End User
7.3.2. Germany Protein Engineering Market Outlook
7.3.2.1. Market Size & Forecast
7.3.2.1.1. By Value
7.3.2.2. Market Share & Forecast
7.3.2.2.1. By Product Type
7.3.2.2.2. By Technology
7.3.2.2.3. By End User
7.3.3. Spain Protein Engineering Market Outlook
7.3.3.1. Market Size & Forecast
7.3.3.1.1. By Value
7.3.3.2. Market Share & Forecast
7.3.3.2.1. By Product Type
7.3.3.2.2. By Technology
7.3.3.2.3. By End User
7.3.4. Italy Protein Engineering Market Outlook
7.3.4.1. Market Size & Forecast
7.3.4.1.1. By Value
7.3.4.2. Market Share & Forecast
7.3.4.2.1. By Product Type
7.3.4.2.2. By Technology
7.3.4.2.3. By End User
7.3.5. United Kingdom Protein Engineering Market Outlook
7.3.5.1. Market Size & Forecast
7.3.5.1.1. By Value
7.3.5.2. Market Share & Forecast
7.3.5.2.1. By Product Type
7.3.5.2.2. By Technology
7.3.5.2.3. By End User
8. North America Protein Engineering Market Outlook
8.1. Market Size & Forecast
8.1.1. By Value
8.2. Market Share & Forecast
8.2.1. By Product Type
8.2.2. By Technology
8.2.3. By End User
8.2.4. By Country
8.3. North America: Country Analysis
8.3.1. United States Protein Engineering Market Outlook
8.3.1.1. Market Size & Forecast
8.3.1.1.1. By Value
8.3.1.2. Market Share & Forecast
8.3.1.2.1. By Product Type
8.3.1.2.2. By Technology
8.3.1.2.3. By End User
8.3.2. Mexico Protein Engineering Market Outlook
8.3.2.1. Market Size & Forecast
8.3.2.1.1. By Value
8.3.2.2. Market Share & Forecast
8.3.2.2.1. By Product Type
8.3.2.2.2. By Technology
8.3.2.2.3. By End User
8.3.3. Canada Protein Engineering Market Outlook
8.3.3.1. Market Size & Forecast
8.3.3.1.1. By Value
8.3.3.2. Market Share & Forecast
8.3.3.2.1. By Product Type
8.3.3.2.2. By Technology
8.3.3.2.3. By End User
9. South America Protein Engineering Market Outlook
9.1. Market Size & Forecast
9.1.1. By Value
9.2. Market Share & Forecast
9.2.1. By Product Type
9.2.2. By Technology
9.2.3. By End User
9.2.4. By Country
9.3. South America: Country Analysis
9.3.1. Brazil Protein Engineering Market Outlook
9.3.1.1. Market Size & Forecast
9.3.1.1.1. By Value
9.3.1.2. Market Share & Forecast
9.3.1.2.1. By Product Type
9.3.1.2.2. By Technology
9.3.1.2.3. By End User
9.3.2. Argentina Protein Engineering Market Outlook
9.3.2.1. Market Size & Forecast
9.3.2.1.1. By Value
9.3.2.2. Market Share & Forecast
9.3.2.2.1. By Product Type
9.3.2.2.2. By Technology
9.3.2.2.3. By End User
9.3.3. Colombia Protein Engineering Market Outlook
9.3.3.1. Market Size & Forecast
9.3.3.1.1. By Value
9.3.3.2. Market Share & Forecast
9.3.3.2.1. By Product Type
9.3.3.2.2. By Technology
9.3.3.2.3. By End User
10. Middle East and Africa Protein Engineering Market Outlook
10.1. Market Size & Forecast
10.1.1. By Value
10.2. Market Share & Forecast
10.2.1. By Product Type
10.2.2. By Technology
10.2.3. By End User
10.2.4. By Country
10.3. MEA: Country Analysis
10.3.1. South Africa Protein Engineering Market Outlook
10.3.1.1. Market Size & Forecast
10.3.1.1.1. By Value
10.3.1.2. Market Share & Forecast
10.3.1.2.1. By Product Type
10.3.1.2.2. By Technology
10.3.1.2.3. By End User
10.3.2. Saudi Arabia Protein Engineering Market Outlook
10.3.2.1. Market Size & Forecast
10.3.2.1.1. By Value
10.3.2.2. Market Share & Forecast
10.3.2.2.1. By Product Type
10.3.2.2.2. By Technology
10.3.2.2.3. By End User
10.3.3. UAE Protein Engineering Market Outlook
10.3.3.1. Market Size & Forecast
10.3.3.1.1. By Value
10.3.3.2. Market Share & Forecast
10.3.3.2.1. By Product Type
10.3.3.2.2. By Technology
10.3.3.2.3. By End User
11. Market Dynamics
11.1. Drivers
11.2. Challenges
12. Market Trends & Developments
12.1. Recent Developments
12.2. Product Launches
12.3. Mergers & Acquisitions
13. Global Protein Engineering Market: SWOT Analysis
14. Porter’s Five Forces Analysis
14.1. Competition in the Industry
14.2. Potential of New Entrants
14.3. Power of Suppliers
14.4. Power of Customers
14.5. Threat of Substitute Product
15. PESTLE Analysis
16. Competitive Landscape
16.1. Agilent Technologies Inc.
16.1.1. Business Overview
16.1.2. Company Snapshot
16.1.3. Products & Services
16.1.4. Financials (In case of listed companies)
16.1.5. Recent Developments
16.1.6. Key Personnel Details

16.1.7. SWOT Analysis
16.2. Amgen Inc.
16.3. Bruker Corporation
16.4. Bio-Rad Laboratories Inc.
16.5. Eli Lilly and Company
16.6. Merck KGaA
16.7. Novo Nordisk AS
16.8. PerkinElmer Inc.
16.9. Thermo Fisher Scientific Inc.
16.10.Waters Corporation
17. Strategic Recommendations
18. About Us & Disclaimer