Summary

The global market for High-performance Liquid Chromatography (HPLC) was estimated to be worth US$ 3529 million in 2024 and is forecast to a readjusted size of US$ 4416 million by 2031 with a CAGR of 3.3% during the forecast period 2025-2031.
This report provides a comprehensive assessment of recent tariff adjustments and international strategic countermeasures on High-performance Liquid Chromatography (HPLC) cross-border industrial footprints, capital allocation patterns, regional economic interdependencies, and supply chain reconfigurations.
High-performance liquid chromatography (HPLC) is a technique in analytic chemistry used to separate the components in a mixture, to identify each component, and to quantify each component. It relies on pumps to pass a pressurized liquid solvent containing the sample mixture through a column filled with a solid adsorbent material. Each component in the sample interacts slightly differently with the adsorbent material, causing different flow rates for the different components and leading to the separation of the components as they flow out the column.
Market Development Opportunities & Main Driving Factors
Driven by the growing need for high-precision and high-throughput analytical methods in pharmaceuticals, biotechnology, food safety, and environmental monitoring, the HPLC market is experiencing steady expansion. Particularly in drug discovery, biologics analysis, and metabolomics research, HPLC has become a core analytical tool. Additionally, stricter regulatory standards for pharmaceuticals, food products, and environmental safety are prompting greater investment in advanced analytical instruments, thereby boosting market growth.
Market Challenges, Risks, & Restraints
Despite its promising outlook, the HPLC sector faces challenges such as high equipment costs, complex operation and maintenance requirements, and a shortage of skilled professionals—especially in emerging markets. Moreover, the risk of technological substitution must be considered, with newer techniques like Ultra Performance Liquid Chromatography (UPLC) potentially replacing conventional HPLC systems in some applications, reshaping the market landscape.
Downstream Demand Trends
Downstream demand is shifting from traditional pharmaceutical testing to more diversified applications, including biopharmaceuticals, food additives, cosmetic ingredients, and environmental toxins. With the rise of precision medicine and personalized therapies, clinical sample analysis and pharmacokinetic studies are driving continued demand for HPLC systems with higher sensitivity and advanced data processing capabilities.
EU is the largest High-performance Liquid Chromatography (HPLC) market with about 34% market share. US is follower, accounting for about 34% market share. The key players are Agilent, Waters, Shimadzu, Thermo Fisher, PerkinElmer, Hitachi, Jasco, Knauer, Bekman, YoungLin, GBC, Gilson etc. Top 3 companies occupied about 66% market share.
This report aims to provide a comprehensive presentation of the global market for High-performance Liquid Chromatography (HPLC), focusing on the total sales volume, sales revenue, price, key companies market share and ranking, together with an analysis of High-performance Liquid Chromatography (HPLC) by region & country, by Type, and by Application.
The High-performance Liquid Chromatography (HPLC) market size, estimations, and forecasts are provided in terms of sales volume (K Units) and sales revenue ($ millions), considering 2024 as the base year, with history and forecast data for the period from 2020 to 2031. With both quantitative and qualitative analysis, to help readers develop business/growth strategies, assess the market competitive situation, analyze their position in the current marketplace, and make informed business decisions regarding High-performance Liquid Chromatography (HPLC).
Market Segmentation
By Company
Agilent
Waters
Shimadzu
Thermo Fisher
PerkinElmer
Hitachi
Jasco
Knauer
Bekman
YoungLin
GBC
Gilson
Segment by Type
UVS
FD
RID
ED
CD
Segment by Application
Pharmacy
Biotechnology
CROs
Academia
Chemicals
Others
By Region
North America
United States
Canada
Asia-Pacific
China
Japan
South Korea
Southeast Asia
India
Australia
Rest of Asia-Pacific
Europe
Germany
France
U.K.
Italy
Netherlands
Nordic Countries
Rest of Europe
Latin America
Mexico
Brazil
Rest of Latin America
Middle East & Africa
Turkey
Saudi Arabia
UAE
Rest of MEA
Chapter Outline
Chapter 1: Introduces the report scope of the report, global total market size (value, volume and price). This chapter also provides the market dynamics, latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by manufacturers in the industry, and the analysis of relevant policies in the industry.
Chapter 2: Detailed analysis of High-performance Liquid Chromatography (HPLC) manufacturers competitive landscape, price, sales and revenue market share, latest development plan, merger, and acquisition information, etc.
Chapter 3: Provides the analysis of various market segments by Type, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.
Chapter 4: Provides the analysis of various market segments by Application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.
Chapter 5: Sales, revenue of High-performance Liquid Chromatography (HPLC) in regional level. It provides a quantitative analysis of the market size and development potential of each region and introduces the market development, future development prospects, market space, and market size of each country in the world.
Chapter 6: Sales, revenue of High-performance Liquid Chromatography (HPLC) in country level. It provides sigmate data by Type, and by Application for each country/region.
Chapter 7: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including product sales, revenue, price, gross margin, product introduction, recent development, etc.
Chapter 8: Analysis of industrial chain, including the upstream and downstream of the industry.
Chapter 9: Conclusion.

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Table of Contents

1 Market Overview
1.1 High-performance Liquid Chromatography (HPLC) Product Introduction
1.2 Global High-performance Liquid Chromatography (HPLC) Market Size Forecast
1.2.1 Global High-performance Liquid Chromatography (HPLC) Sales Value (2020-2031)
1.2.2 Global High-performance Liquid Chromatography (HPLC) Sales Volume (2020-2031)
1.2.3 Global High-performance Liquid Chromatography (HPLC) Sales Price (2020-2031)
1.3 High-performance Liquid Chromatography (HPLC) Market Trends & Drivers
1.3.1 High-performance Liquid Chromatography (HPLC) Industry Trends
1.3.2 High-performance Liquid Chromatography (HPLC) Market Drivers & Opportunity
1.3.3 High-performance Liquid Chromatography (HPLC) Market Challenges
1.3.4 High-performance Liquid Chromatography (HPLC) Market Restraints
1.4 Assumptions and Limitations
1.5 Study Objectives
1.6 Years Considered
2 Competitive Analysis by Company
2.1 Global High-performance Liquid Chromatography (HPLC) Players Revenue Ranking (2024)
2.2 Global High-performance Liquid Chromatography (HPLC) Revenue by Company (2020-2025)
2.3 Global High-performance Liquid Chromatography (HPLC) Players Sales Volume Ranking (2024)
2.4 Global High-performance Liquid Chromatography (HPLC) Sales Volume by Company Players (2020-2025)
2.5 Global High-performance Liquid Chromatography (HPLC) Average Price by Company (2020-2025)
2.6 Key Manufacturers High-performance Liquid Chromatography (HPLC) Manufacturing Base and Headquarters
2.7 Key Manufacturers High-performance Liquid Chromatography (HPLC) Product Offered
2.8 Key Manufacturers Time to Begin Mass Production of High-performance Liquid Chromatography (HPLC)
2.9 High-performance Liquid Chromatography (HPLC) Market Competitive Analysis
2.9.1 High-performance Liquid Chromatography (HPLC) Market Concentration Rate (2020-2025)
2.9.2 Global 5 and 10 Largest Manufacturers by High-performance Liquid Chromatography (HPLC) Revenue in 2024
2.9.3 Global Top Manufacturers by Company Type (Tier 1, Tier 2, and Tier 3) & (based on the Revenue in High-performance Liquid Chromatography (HPLC) as of 2024)
2.10 Mergers & Acquisitions, Expansion
3 Segmentation by Type
3.1 Introduction by Type
3.1.1 UVS
3.1.2 FD
3.1.3 RID
3.1.4 ED
3.1.5 CD
3.2 Global High-performance Liquid Chromatography (HPLC) Sales Value by Type
3.2.1 Global High-performance Liquid Chromatography (HPLC) Sales Value by Type (2020 VS 2024 VS 2031)
3.2.2 Global High-performance Liquid Chromatography (HPLC) Sales Value, by Type (2020-2031)
3.2.3 Global High-performance Liquid Chromatography (HPLC) Sales Value, by Type (%) (2020-2031)
3.3 Global High-performance Liquid Chromatography (HPLC) Sales Volume by Type
3.3.1 Global High-performance Liquid Chromatography (HPLC) Sales Volume by Type (2020 VS 2024 VS 2031)
3.3.2 Global High-performance Liquid Chromatography (HPLC) Sales Volume, by Type (2020-2031)
3.3.3 Global High-performance Liquid Chromatography (HPLC) Sales Volume, by Type (%) (2020-2031)
3.4 Global High-performance Liquid Chromatography (HPLC) Average Price by Type (2020-2031)
4 Segmentation by Application
4.1 Introduction by Application
4.1.1 Pharmacy
4.1.2 Biotechnology
4.1.3 CROs
4.1.4 Academia
4.1.5 Chemicals
4.1.6 Others
4.2 Global High-performance Liquid Chromatography (HPLC) Sales Value by Application
4.2.1 Global High-performance Liquid Chromatography (HPLC) Sales Value by Application (2020 VS 2024 VS 2031)
4.2.2 Global High-performance Liquid Chromatography (HPLC) Sales Value, by Application (2020-2031)
4.2.3 Global High-performance Liquid Chromatography (HPLC) Sales Value, by Application (%) (2020-2031)
4.3 Global High-performance Liquid Chromatography (HPLC) Sales Volume by Application
4.3.1 Global High-performance Liquid Chromatography (HPLC) Sales Volume by Application (2020 VS 2024 VS 2031)
4.3.2 Global High-performance Liquid Chromatography (HPLC) Sales Volume, by Application (2020-2031)
4.3.3 Global High-performance Liquid Chromatography (HPLC) Sales Volume, by Application (%) (2020-2031)
4.4 Global High-performance Liquid Chromatography (HPLC) Average Price by Application (2020-2031)
5 Segmentation by Region
5.1 Global High-performance Liquid Chromatography (HPLC) Sales Value by Region
5.1.1 Global High-performance Liquid Chromatography (HPLC) Sales Value by Region: 2020 VS 2024 VS 2031
5.1.2 Global High-performance Liquid Chromatography (HPLC) Sales Value by Region (2020-2025)
5.1.3 Global High-performance Liquid Chromatography (HPLC) Sales Value by Region (2026-2031)
5.1.4 Global High-performance Liquid Chromatography (HPLC) Sales Value by Region (%), (2020-2031)
5.2 Global High-performance Liquid Chromatography (HPLC) Sales Volume by Region
5.2.1 Global High-performance Liquid Chromatography (HPLC) Sales Volume by Region: 2020 VS 2024 VS 2031
5.2.2 Global High-performance Liquid Chromatography (HPLC) Sales Volume by Region (2020-2025)
5.2.3 Global High-performance Liquid Chromatography (HPLC) Sales Volume by Region (2026-2031)
5.2.4 Global High-performance Liquid Chromatography (HPLC) Sales Volume by Region (%), (2020-2031)
5.3 Global High-performance Liquid Chromatography (HPLC) Average Price by Region (2020-2031)
5.4 North America
5.4.1 North America High-performance Liquid Chromatography (HPLC) Sales Value, 2020-2031
5.4.2 North America High-performance Liquid Chromatography (HPLC) Sales Value by Country (%), 2024 VS 2031
5.5 Europe
5.5.1 Europe High-performance Liquid Chromatography (HPLC) Sales Value, 2020-2031
5.5.2 Europe High-performance Liquid Chromatography (HPLC) Sales Value by Country (%), 2024 VS 2031
5.6 Asia Pacific
5.6.1 Asia Pacific High-performance Liquid Chromatography (HPLC) Sales Value, 2020-2031
5.6.2 Asia Pacific High-performance Liquid Chromatography (HPLC) Sales Value by Region (%), 2024 VS 2031
5.7 South America
5.7.1 South America High-performance Liquid Chromatography (HPLC) Sales Value, 2020-2031
5.7.2 South America High-performance Liquid Chromatography (HPLC) Sales Value by Country (%), 2024 VS 2031
5.8 Middle East & Africa
5.8.1 Middle East & Africa High-performance Liquid Chromatography (HPLC) Sales Value, 2020-2031
5.8.2 Middle East & Africa High-performance Liquid Chromatography (HPLC) Sales Value by Country (%), 2024 VS 2031
6 Segmentation by Key Countries/Regions
6.1 Key Countries/Regions High-performance Liquid Chromatography (HPLC) Sales Value Growth Trends, 2020 VS 2024 VS 2031
6.2 Key Countries/Regions High-performance Liquid Chromatography (HPLC) Sales Value and Sales Volume
6.2.1 Key Countries/Regions High-performance Liquid Chromatography (HPLC) Sales Value, 2020-2031
6.2.2 Key Countries/Regions High-performance Liquid Chromatography (HPLC) Sales Volume, 2020-2031
6.3 United States
6.3.1 United States High-performance Liquid Chromatography (HPLC) Sales Value, 2020-2031
6.3.2 United States High-performance Liquid Chromatography (HPLC) Sales Value by Type (%), 2024 VS 2031
6.3.3 United States High-performance Liquid Chromatography (HPLC) Sales Value by Application, 2024 VS 2031
6.4 Europe
6.4.1 Europe High-performance Liquid Chromatography (HPLC) Sales Value, 2020-2031
6.4.2 Europe High-performance Liquid Chromatography (HPLC) Sales Value by Type (%), 2024 VS 2031
6.4.3 Europe High-performance Liquid Chromatography (HPLC) Sales Value by Application, 2024 VS 2031
6.5 China
6.5.1 China High-performance Liquid Chromatography (HPLC) Sales Value, 2020-2031
6.5.2 China High-performance Liquid Chromatography (HPLC) Sales Value by Type (%), 2024 VS 2031
6.5.3 China High-performance Liquid Chromatography (HPLC) Sales Value by Application, 2024 VS 2031
6.6 Japan
6.6.1 Japan High-performance Liquid Chromatography (HPLC) Sales Value, 2020-2031
6.6.2 Japan High-performance Liquid Chromatography (HPLC) Sales Value by Type (%), 2024 VS 2031
6.6.3 Japan High-performance Liquid Chromatography (HPLC) Sales Value by Application, 2024 VS 2031
6.7 South Korea
6.7.1 South Korea High-performance Liquid Chromatography (HPLC) Sales Value, 2020-2031
6.7.2 South Korea High-performance Liquid Chromatography (HPLC) Sales Value by Type (%), 2024 VS 2031
6.7.3 South Korea High-performance Liquid Chromatography (HPLC) Sales Value by Application, 2024 VS 2031
6.8 Southeast Asia
6.8.1 Southeast Asia High-performance Liquid Chromatography (HPLC) Sales Value, 2020-2031
6.8.2 Southeast Asia High-performance Liquid Chromatography (HPLC) Sales Value by Type (%), 2024 VS 2031
6.8.3 Southeast Asia High-performance Liquid Chromatography (HPLC) Sales Value by Application, 2024 VS 2031
6.9 India
6.9.1 India High-performance Liquid Chromatography (HPLC) Sales Value, 2020-2031
6.9.2 India High-performance Liquid Chromatography (HPLC) Sales Value by Type (%), 2024 VS 2031
6.9.3 India High-performance Liquid Chromatography (HPLC) Sales Value by Application, 2024 VS 2031
7 Company Profiles
7.1 Agilent
7.1.1 Agilent Company Information
7.1.2 Agilent Introduction and Business Overview
7.1.3 Agilent High-performance Liquid Chromatography (HPLC) Sales, Revenue, Price and Gross Margin (2020-2025)
7.1.4 Agilent High-performance Liquid Chromatography (HPLC) Product Offerings
7.1.5 Agilent Recent Development
7.2 Waters
7.2.1 Waters Company Information
7.2.2 Waters Introduction and Business Overview
7.2.3 Waters High-performance Liquid Chromatography (HPLC) Sales, Revenue, Price and Gross Margin (2020-2025)
7.2.4 Waters High-performance Liquid Chromatography (HPLC) Product Offerings
7.2.5 Waters Recent Development
7.3 Shimadzu
7.3.1 Shimadzu Company Information
7.3.2 Shimadzu Introduction and Business Overview
7.3.3 Shimadzu High-performance Liquid Chromatography (HPLC) Sales, Revenue, Price and Gross Margin (2020-2025)
7.3.4 Shimadzu High-performance Liquid Chromatography (HPLC) Product Offerings
7.3.5 Shimadzu Recent Development
7.4 Thermo Fisher
7.4.1 Thermo Fisher Company Information
7.4.2 Thermo Fisher Introduction and Business Overview
7.4.3 Thermo Fisher High-performance Liquid Chromatography (HPLC) Sales, Revenue, Price and Gross Margin (2020-2025)
7.4.4 Thermo Fisher High-performance Liquid Chromatography (HPLC) Product Offerings
7.4.5 Thermo Fisher Recent Development
7.5 PerkinElmer
7.5.1 PerkinElmer Company Information
7.5.2 PerkinElmer Introduction and Business Overview
7.5.3 PerkinElmer High-performance Liquid Chromatography (HPLC) Sales, Revenue, Price and Gross Margin (2020-2025)
7.5.4 PerkinElmer High-performance Liquid Chromatography (HPLC) Product Offerings
7.5.5 PerkinElmer Recent Development
7.6 Hitachi
7.6.1 Hitachi Company Information
7.6.2 Hitachi Introduction and Business Overview
7.6.3 Hitachi High-performance Liquid Chromatography (HPLC) Sales, Revenue, Price and Gross Margin (2020-2025)
7.6.4 Hitachi High-performance Liquid Chromatography (HPLC) Product Offerings
7.6.5 Hitachi Recent Development
7.7 Jasco
7.7.1 Jasco Company Information
7.7.2 Jasco Introduction and Business Overview
7.7.3 Jasco High-performance Liquid Chromatography (HPLC) Sales, Revenue, Price and Gross Margin (2020-2025)
7.7.4 Jasco High-performance Liquid Chromatography (HPLC) Product Offerings
7.7.5 Jasco Recent Development
7.8 Knauer
7.8.1 Knauer Company Information
7.8.2 Knauer Introduction and Business Overview
7.8.3 Knauer High-performance Liquid Chromatography (HPLC) Sales, Revenue, Price and Gross Margin (2020-2025)
7.8.4 Knauer High-performance Liquid Chromatography (HPLC) Product Offerings
7.8.5 Knauer Recent Development
7.9 Bekman
7.9.1 Bekman Company Information
7.9.2 Bekman Introduction and Business Overview
7.9.3 Bekman High-performance Liquid Chromatography (HPLC) Sales, Revenue, Price and Gross Margin (2020-2025)
7.9.4 Bekman High-performance Liquid Chromatography (HPLC) Product Offerings
7.9.5 Bekman Recent Development
7.10 YoungLin
7.10.1 YoungLin Company Information
7.10.2 YoungLin Introduction and Business Overview
7.10.3 YoungLin High-performance Liquid Chromatography (HPLC) Sales, Revenue, Price and Gross Margin (2020-2025)
7.10.4 YoungLin High-performance Liquid Chromatography (HPLC) Product Offerings
7.10.5 YoungLin Recent Development
7.11 GBC
7.11.1 GBC Company Information
7.11.2 GBC Introduction and Business Overview
7.11.3 GBC High-performance Liquid Chromatography (HPLC) Sales, Revenue, Price and Gross Margin (2020-2025)
7.11.4 GBC High-performance Liquid Chromatography (HPLC) Product Offerings
7.11.5 GBC Recent Development
7.12 Gilson
7.12.1 Gilson Company Information
7.12.2 Gilson Introduction and Business Overview
7.12.3 Gilson High-performance Liquid Chromatography (HPLC) Sales, Revenue, Price and Gross Margin (2020-2025)
7.12.4 Gilson High-performance Liquid Chromatography (HPLC) Product Offerings
7.12.5 Gilson Recent Development
8 Industry Chain Analysis
8.1 High-performance Liquid Chromatography (HPLC) Industrial Chain
8.2 High-performance Liquid Chromatography (HPLC) Upstream Analysis
8.2.1 Key Raw Materials
8.2.2 Raw Materials Key Suppliers
8.2.3 Manufacturing Cost Structure
8.3 Midstream Analysis
8.4 Downstream Analysis (Customers Analysis)
8.5 Sales Model and Sales Channels
8.5.1 High-performance Liquid Chromatography (HPLC) Sales Model
8.5.2 Sales Channel
8.5.3 High-performance Liquid Chromatography (HPLC) Distributors
9 Research Findings and Conclusion
10 Appendix
10.1 Research Methodology
10.1.1 Methodology/Research Approach
10.1.1.1 Research Programs/Design
10.1.1.2 Market Size Estimation
10.1.1.3 Market Breakdown and Data Triangulation
10.1.2 Data Source
10.1.2.1 Secondary Sources
10.1.2.2 Primary Sources
10.2 Author Details
10.3 Disclaimer